Background: Substance use related problems are globally prevalent and remain an ongoing health crisis affecting every region of the world.Overall in India, opioids are the third most common psychoactive substance used by Indians. Persons with opioid related problems are in need of help for the same.Knowledge of their socio demographic profile, pattern of opioid consumption and associated factors like substance consumption in their families, presence of any mental disorderetc may help for the same. Method: A cross-sectional study was conducted on 119 patients of opioid dependence seeking treatment at psychiatry OPD of tertiary health care centre of southern Rajasthan. A self-designed semi-structured proforma was used to gather information regarding sociodemographic variables and the associated factors. The results were examined and analyzed by using Statistical Package for Social Sciences. Results: Majority of the participants were male, from rural background, married, employed, hailing from joint family, from upper lower socioeconomic status and were consuming natural opioids. Current study also shows various reasons to start opioids, ways to procure it for the first time, reasons to restart opioid, and current reasons to quit the same. Conclusions: Findings of the current study show that the participants initiated opioid consumption at the productive years of their life with raw opioid being preferred type. Majority of them were also consuming nicotine. In an attempt to procure opioids they have to shell out significant amount of money that could have been utilized to fulfil the needs of their daily livelihood. Previous attempt to quit the substance shows their motivation.