Delayed wound healing particularly in difficult wounds and in elderly with co morbidities is a major concern. It leads to the pain, morbidity, prolonged treatment, and require major reconstructive surgery which imposes enormous social and financial burden. Vacuum-assisted closure (VAC) is an alternative method of wound management, which uses the negative pressure to prepare the wound for spontaneous healing or by lesser reconstructive options. Method of VAC application includes thorough debridement, adequate haemostasis and application of sterile foams dressing. A fenestrated tube is embedded in the foam and wound is sealed with adhesive tape to make it air tight. The fenestrate tube is connected to a vacuum pump with fluid collection container. The machine delivers continuous or intermittent suction,ranging from 50 to 125 mmHg. The VAC dressings are changed on 3rd day. Negative pressure therapy stabilizes the wound environment, reduces wound edema/bacterial load, improves tissue perfusion, and stimulates granulation tissue and angiogenesis. All this improves the possibility of primary closure of wounds and reduce the need for plastic procedures. VAC therapy appears to be a simple and more effective than conventional dressings for the management of difficult wound in terms of reduction in wound volume, depth, treatment duration and cost. Objectives: To study the Clinical, functional outcome of Vacuum-Assisted Closure (VAC) and its efficiency. Methodology: This study was conducted in Department of Orthopaedics, Navodaya Medical College Hospital and Research Centre, Raichur, From January 2021 to June 2021, a total of 50 patients were selected based upon chronic non healing wound and Cases and controls are selected from the same wards at different time period. Total 25 cases and 25 controls were selected and were randomized at the time of admission. Results: V.A.C dressing reduces Hospital stay and helps improve pus culture sterility. It improves outcome by decreasing the number of amputations and increases the number of patients undergoing skin grafting. Interpretation and Conclusion: Vacuum-Assisted Closure (VAC) is very effective in reducing the size of wound and facilitates wound healing.