Background: The present study was undertaken for assessing the efficacy of three-port laparoscopic cholecystectomy in gall stone patients. Materials & methods: 50 gallstone patients were enrolled in the present study. Demographic data of all the patients was obtained. 3-port laparoscopic cholecystectomy was carried out. A 10-mm supraumbilical port, 10-mm subxiphoid, and 5-mm subcostal port was used. Our primary outcome measure was pain score after surgery. All the results were recorded in Microsoft excel sheet and were analysed by SPSS software. Results: Fifty gallstone patients scheduled to undergo 3-port LC were included. Mean age of the patients was 46.9 years. Overall, wound infection was present in 8 percent of the patients. Mean VAS score evaluating the postoperative pain at on day of surgery at 6 hours, at discharge, at one-week follow-up and at two-weeks follow-up was 6.29, 3.13, 2.04 and 1.12 respectively. While evaluating statistically, significant results were obtained. Mean duration of hospital stay was found to be 1.9 days. Conclusion: Three port technique is a safe technique for laparoscopic cholecystectomy.