Background: This study was done to conduct the Retrospective assessment of Targeted Endodontic Microsurgery. Material and methods:A database was searched for potential cases, and 20 patients were selected. Trained endodontists completed a calibration exercise before evaluating radiographs, and then a retrospective outcomes assessment took into account follow-up clinical and radiographic findings to assign one of three healing designations: complete healing, reductive healing, or failure. All the results were recorded in Microsoft excel sheet followed by a statistical analysis using SPSS software. Results:The combined clinical and radiographic data led to 12 cases being designated as having complete healing, 7 cases being designated as having reductive healing, and 1 case being designated as failing, which resulted in a success rate of 95%.Conclusion: Targeted endodontic microsurgery leads to successful outcomes. It would be prudent to do controlled clinical tests with follow-up over an extended period of time.