Background: It has been determined that providing care is a fundamental aspect of human nature and a foundational aspect of close relationships. The present study was conducted to assess burden of care among caregivers of patients with schizophrenia and bipolar disorder. Materials & Methods: 50 patients of schizophrenia and bipolar disorders of both genders were selected and parameters such as duration of illness, duration of treatment, number of hospitalization, duration of caregiving etc. was recorded. Results: Out of 50 patients, males were 32 and females were 18. Duration of illness was 7.1 years in group I and 9.4 years in group II, duration of treatment was 5.4 years in group I and 7.6 years in group II, number of hospitalization was 0.8 and 0.9 and duration of care giving was 7.5 and 8.3 in group I and II respectively. The difference was significant (P< 0.05). BAS total score was 69.8 in group I and 69.1 in group II. The difference was significant (P< 0.05). Conclusion: Families of people with schizophrenia experience a greater strain than those of individuals with bipolar illness. Families of bipolar disorder suffer from a significant burden as well.