Original Articles
Correlation of serum uric acid in subclinical target organ dysfunction in hypertensive population | |
Dr. Bhavani MS, Dr. Siddarth GR | |
Serum uric acid (SUA) plays a role in the development of cardiovascular morbidly in the general population. The presence of subclinical hypertensive organ damage signals a condition of increased risk for cardiovascular, renal, morbidity and mortality. Thus, the search for left ventricular hypertrophy (LVH), carotid atherosclerosis, and microalbiminuria, which are likely to reflect both the severity of blood pressure load and other non-hemodynamic risk factors, is currently recommended as part of global risk assessment. The participants were clearly explained about the objectives and informed consent was obtained. All participants fulfilling the inclusion criteria were interviewed and detailed clinical examination was done. In this study 120 patients with recently diagnosed hypertension attending the outpatient clinic of our institution were studied. Albuminuria, Left ventricular mass index and carotid intima-media thickness were assessed for all patients. Uric acid levels correlated significantly with target organ damage indices. The correlation of uric acid was with LV mass index was the strongest when compared with that of microalbuminuria and carotid IMT. Serum uric acid levels positively correlated with number of target organs involved. However the direct relationship between uric acid and target organ damage was weakened by factors like dyslipidemia and degree of control of blood pressure, which also determined the target organ dysfunction. Serum uric acid levels positively correlated with number of target organs involved. The greater the number of organs involved the higher the uric acid levels. |
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