Introduction: Plasma thromoplastincytoblock technique is a simple , cost effective and readily adaptable in routine hospital laboratories as compared to cell block preparations made from conventional techniques such as agar gel or formol alcohol , which is much laborious and time consuming . We applied the recently proposed International system for reporting serous cytopathology (TIS) on the serous effusions and reported our experience. Aim: To study the diagnostic utility of Thromboplastin cell block technique in conjunction with conventional smears and its classification according to TIS. Material and methods: 114 samples were included in the study over a period of 8 months, both conventional and cell block preparations were made. Result: A total of 114 cases were studied: 64 pleural fluid, 45 ascetic fluid and 05 pericardial fluid. 04 (3.5%) were diagnosed as non diagnostic, 69 (61%) as Negative for malignancy, 10 (8.8%) as Atypia of underterminedsignificance, 12 (10.52%) as Suspicious for malignancy, 19 (16.66%) as Malignant. Cellularity and diagnostic yield for malignancy was increased by cell block preparation. Conclusion: Plasma thromoplastin cell block method provides high cellularity, better architectural patterns and a good preservation of nuclear details. TIS is auser friendly reporting system.