Central venous cannulation is a commonly performed procedure which facilitates resuscitation, nutritional support and long-term vascular access. Two commonly used methods to reduce pain experienced by patient while undergoing placement of internal jugular vein access by local infiltration and cervical plexus block. After obtaining the approval from the Ethical committee and the Institutional review board and obtaining a well-informed written consent, 100 ASA Grade I, II, III patients who were undergoing various elective and emergency surgeries requiring central venous cannulation were chosen. The patients were randomized into two groups using computer generated random number tables. It shows significant difference in patient satisfaction scores between two study groups at all time points during internal jugular vein (IJV) cannulation except time 0 (baseline). Overall patient satisfaction was much better in ultrasound guided intermediate cervical plexus block group during various procedural steps of IJV cannulation.