Background: Smartphone can be called as minicomputer as the features and functions provided are like computer in its mini form and its handy. The present study was conducted to evaluate effect of smart phone usage on cardiovascular and hematological parameters. Materials & Methods:180 subjects using smart phone since 5 years of both genders. Assessment of blood pressure, total WBC count and duration of mobile phone usage per day were recorded. Results: Out of 180 subjects, males were 80 and females were 100. 60 subjects had <1 hour usage and 4000- 11000 TLC, 35 had 1-2 hours usage with 4000-11000 TLC. 45 and 40 had >11000 having <1 hour and 1-2 hours usage respectively. The difference was non- significant (P> 0.05).There were 45 subjects with <1hour mobile usage having 70-80 mm Hg of DBP, 15 (1-2 hours) with 70-80 mm Hg of DBP, 81-90 mm Hg was seen in 30 and 25 with <1 hours and 1-2 hours usage, 25 and 40 had 91-100 mm Hg DBP with <1 hour and 1-2 hours usage respectively. The difference was significant (P< 0.05). Conclusion: Along-term duration of mobile phone use may affect and change the autonomic balance in favour of an increased sympathetic tone. An increase in the sympathetic tone and a concomitant decrease in the parasympathetic tone are reported to be measured among the subjects who have used the mobile phones for prolonged period of time.