Background: Cancer is a prevalent disease in both developing and developed countries. Cancer awareness is important for the prevention and early diagnosis and treatment of cancer. Nursing and paramedical staff are the frontline healthcare professionals. Cancer awareness among them is important to disseminate knowledge and take the right measures for the prevention, early diagnosis, and treatment of cancer patients. Aims: This study aims to assess the level of cancer awareness in hospital nurses and paramedical staff about the signs and symptoms of cancer, the risk factors of cancer, and the national cancer screening programs. Materials and Methods: A cross-sectional survey was conducted among nurses and paramedical staff in a tertiary care hospital in central India using a pre-tested self-administered structured questionnaire. A total of 200 nurses and paramedical staff participated in the study voluntarily. Data was collected and analyzed. Results: Our study showed that an average of only 51.2% (n = 102.4) of the subjects were aware of the signs and symptoms of cancer, only 51.45% (n = 102.24) were aware of the risk factors of cancer, and only 59% (n = 118) were aware of the cancer screening programs. Conclusions: Our study showed that there is a significant lack of awareness amongst nurses and paramedical staff in India. It highlights the need to educate and train them in various areas of cancer so that they can provide an additional layer of intervention to improve the prevention, early identification, and prompt treatment of cancer, and to improve global cancer outcomes.