Introduction: Atherosclerosis is an abnormality commonly encountered in patients with chronic kidney disease. The increased risk of atherosclerotic cardiovascular disease may be due to hyperlipidemia. Aims Of The Study To estimate various lipid profile abnormalities in Chronic Kidney Disease patients. To study the correlation between the serum creatinine levels and lipid abnormalities in Chronic Kidney Disease. Materials And Methods: This study was conducted in 50 patients with chronic kidney disease and 50 normal healthy persons. who were admitted to Mahatma Gandhi Memorial Hospital Warangal during September 2018 - September 2020. Results And Observations :Age of the patients varied from 15 yrs to 80 yrs. Majority of patients fall in the age group between 26-55 years. Seventy two percentage of people contribute this group. Discussion: In our study, most common lipid abnormalities found were low HDL levels (50%) and hypertriglyceridemia (48%). Conclusion: HDL-C levels were lower and triglycerides, total cholesterol and LDL-C levels were higher in the study group compared to controls. All were statistically significant. Predominant lipid abnormality was reduced HDL-C levels.