Background: Small bowel pathologies is an enigma for clinicians to assess and investigate. The present study was conducted to explore the feasibility of computed tomography enterography (CTE) in the qualitative and quantitative evaluation of the activity of Crohn’s disease (CD) using a patterned approach. Materials & Methods: 43 patients with Crohn’s disease (CD) of both genderswere subjected to CTE. Helical CT scanner – fourth generation 256 slice CT somatom. Results: Active Crohn’s disease was seen maximally in age group 20-30 years (10) and chronic form in age group 20-30 years (8). Clinical features were pain abdomen in 38, altered bowel habits in 35 and weight loss in 8 patients. The location was ileum in 100% in active form, mural enhancement was double halo/ target appearance in 85.7% in active form and 73.4% in chronic form. Mural stratification was maintained in 100%. Length of involvement was focal (< 5 cm) in 6 (21.4%) and 3 (20%) and segmental (6-40 cm) in 22 (78.5%) and 12 (80%) in active and chronic form respectively. Mesentric vascular prominence (Comb sign) was seen in 92.8% and 20%, Mesentric fat stranding was present in 71.4% and 13.3%, Mesentric fibrofatty proliferation was present in 21.4% and 80% in active and chronic crohn’s disease respectively. Conclusion: A careful analysis of several CT parameters in a patterned approach helps to indicate diagnosis and assess disease activity of Crohn’s disease, differentiating active Crohn’s disease from chronic Crohn’s disease.