Background: The present study was conducted for comparing Patients Undergoing Balloon Therapy Alone versus Patients undergoing Balloon Therapy with Medical Management. Materials & methods: A total of 60 patients scheduled to undergo bariatric surgery were enrolled. Complete details of all the patients were recorded. All the patients were divided into two study groups as follows:SB Group- 30 patients in which balloon therapy was done alone while, SB+S Group- 30 patients undergoing Balloon Therapy with Medical Management Outcome was recorded separately. Assessment of all the results was done using SPSS Software. Results: Mean age of the patients of the SB group and SB + S group was 42.7 years and 42.3 years respectively. 43.3 percent of the patients each of the SB group and SB + S group were females. Mean height of the patients of group SB and SB+S was 166.7±9.8 cm and166.7±12.8 cm respectively. Mean total weight loss among the patients of SB group and SB+S group at 4 months interval was 15.6 percent and 20.9 percent respectively. Significant results were obtained while comparing the mean total weight loss among the patients of the two study groups.At less than 1 week, nausea and vomiting was seen in 23.3 percent of the patients of the SB group and 30 percent of the patients of the SB+S group. Conclusion: Combination therapy of balloon with semaglutide is well tolerated over 4-months period and showed clinically relevant better weight loss and reduction in comorbidities with all doses as compared to balloon therapy alone.