Background: There are very few studies on the autologous blood transfusion in ruptured ectopic pregnancy and its comparison with homologous blood transfusion. Therefore, the present study is conducted to evaluate the safety of autologous blood transfusion in ruptured ectopic pregnancy and comparison of autologous blood transfusion with homologous blood transfusion. Materials and method: Ectopic pregnancy was diagnosed on the basis of detailed history (amenorr hoea, pain, bleeding PV), clinical examination, urine pregnancy test and imaging. CBC, blood group, HIV, HBs Ag was done in all patients. In autologous group CBC and prothrombin time was done in preoperative, postoperative period and in peritoneal blood. Blood sent for cross match. Isotonic fluid started in all patients. Informed consent for laparo to my, autologous and homologous blood transfusion was obtained from patients and legal guardian. Patients were divided in to two groups according to their transfusion 1. Homologous blood transfusion - 50 patients 2. Autologous blood transfusion - 50 patients All patients were prepared for laparotomy, general anaesthesia was given to all patients. Manual method was used for cell salvage for autologous blood transfusion in 50 patients. Urine pregnancy test was found positive in all 86 patients, weakly positive in 12 and negative in 2 patients. Results: Both the groups were compared in terms of gravida wise distribution which was statistically insignificant (p>0.05). Majority of the patients were multigravida (91%) as compared to Primi gravida (9%). Mean systolic blood pressure was significantly higher post operatively as compared to pre operative findings in homologous group (116.58mmHg vs 96.02) and Autologous group (114.98mm Hg vs 92.16mmHg) with p value of 0.001. This shows that rupture ectopic patient’s status improved after blood transfusion. ared to pre operative findings in homologous group (77.64mmHg vs 58.80) and Autologous group (76.66mmHg vs 58.78mmHg) with p value of less than 0.05.Mean pulse rate was significantly lower post operatively as compared to pre operative findings in homologous group (88.26 vs 121.14) and Autologous group (85.58 vs 122.12) with p value of 0.001. As normal pulse rate is an indicator of improvement in patients Pre operative mean hemoglobin level was same in both groups no statistically difference was found between both the groups (p>0.05). However, post operative mean hemoglobin was significantly higher in autologous group (8.88gm/dl) as compared to homologous group (8.06gm/dl) as revealed by significant p value of 0.01. A significant haemoconcentration was found in peritoneal blood was responsible for more hemoglobin rise autologous blood transfusion. Pre operative mean total leukocyte count was not found statistically different between both the groups (p>0.05). However, post operative mean TLC was significantly lower in autologous group (9575) as compared to homologous group (11393) as revealed by significant p value of 0.001. This low TLC count after autologous transfusion group patients suggest low chances of sepsis in patients hence autologous blood is safe for transfusion however many unexplained reactionary changes occurred in homologous transfusion group that results in its high TLC count Pre and post operative mean platelet counts was not found statistically significant (p>0.05). Conclusion: Autologous blood transfusion provides with good clinical outcomes compared to homologous transfusion in patients with ruptured ectopic pregnancy and severe blood loss.