Background: Cancer has emerged as a major killer disease in India. The present study was conducted to assess the incidence of oral and Oropharyngeal tumors with reference to the total tumors. Materials & Methods: The material for the present study was the biopsies and surgical specimens from patients admitted to one of several teaching hospitals attached to Bangalore Medical College viz. Victoria Hospital/ Vanivilas Hospital/ Sri venkateshwara Institute of ENTr Bowring and Lady Curzon Hospital and Government Dental College. The period of prospective study was from July 1994 to December 1996 and retrospective study was from July 1993 to July 1994. The pertinent history and clinical data of each case were obtained by personal interview with patient, from clinical case sheet and from hospital records. The specimens which were received at the Department of pathology consisted of wedge biopsies and some excision biopsies. Results: During the study period of three and a half years (July 1993 to December 1996) a total of 10,522 specimens were received in the department of pathology Bangalore Medical College. Out of this oral and Oro Pharyngeal tumour biopsies were 115. Neoplasms accounted for 3271 biopsies. There were 2162 benign neoplasms and 1109 malignant neoplasms. Of the total 115 Oral and Oro Pharyngeal tumors 34 were benign tumors and 81 Malignant tumours. Of 115 Oral and oropharyngeal tumors 80 were from the oral cavity and 35 from the Oropharynx accounting for 69.6% and 30.4% of total Oral and Oro pharyngeal tumors respectively. Conclusion: Oral and Oropharyngeal neoplasms (115 cases) comprised 3.5% of overall neoplasms recorded during the study period. Benign tumors of oral cavity and Oropharynx (34 cases) accounted for 1.6% of overall benign tumors and 29.6% of tumors in the oral cavity and oropharynx. Malignant Oral & Oropharyngeal tumors (81 cases) comprised 7.24% of overall malignant tumors and 70.4% of all tumors in the Oral cavity and Oropharynx.