approach to brachial plexus block. Material and Methods: This prospective, randomized, double-blind, placebo-controlled trial included a sample of 50 patients from the American Society of Anesthesiologists physical status I and II categories. These patients were between the ages of 18 and 60 and were scheduled to undergo upper limb surgery. The patients received a supraclavicular brachial plexus block as part of the study. In this study, a total of 50 participants were divided into two groups. Group I, consisting of 25 participants, received a solution containing 30 ml of levobupivacaine with an additional 1 ml of isotonic sodium chloride solution. On the other hand, Group II, also consisting of 25 participants, received a solution containing 30 ml of levobupivacaine along with 1 ml (100 µg) of dexmedetomidine. Results: The average time at which sensory and motor blocks began in Group I was 9.41±1.29 and 14.88±1.85 minutes, respectively. In Group II, the corresponding times were 4.01±1.05 and 4.74±1.29 minutes. The systolic blood pressure (SBP) and diastolic blood pressure (DBP) values observed in Group II were found to be significantly lower compared to those in Group I during the intraoperative period (P < 0.001). In Group II, a total of 20 patients experienced hypotension and 21 patients experienced bradycardia, both of which were observed as adverse effects. Conclusion: We concluded that the inclusion of dexmedetomidine in levobupivacaine for supraclavicular brachial plexus block results in a reduction in the time required for the sensory and motor blocks to take effect, as well as an extension of their duration.