Background: Vitamin deficiencies can lead to a number of physiological and metabolic issues as well as increase the risk of developing diabetes mellitus.Restoring normal serum vitamin D levels may help a number of postmenopausal women's common diseases that are linked to low levels of the hormone including muscle strength. Objective:The aim of this study was to evaluate the effect of weekly vitamin D3 supplementation on metabolic parameters and muscle strength of postmenopausal women with type 2 diabetes. Methods: Type 2 diabetic postmenopausal women were recruited from an outpatient clinic and were divided into 2 groups to receive vehicle versus vitamin D3 supplements along with their regular antidiabetic therapy. Handgrip strength was measured both before and after the intervention. Secondary parameters were related to blood glucose, lipid profle and blood pressure and vitamin D3 level. Comparison was made between 12-week post intervention versus baseline level. Results: Baseline characteristics were not different for the patients in the intervention and control groups. All patients were above the age of 60 years and duration of diabetes was>10 years. At the end of treatment period, the intervention group exhibited notable elevations in blood vitamin D3 levels but it was not seen in the control group. The intervention group exhibited a significant improvement in handgrip strength, as evidenced by the increase in kilograms for both the right arm. Effect was visible in both the hands. Other parameters were not significantly different between intervention and control group. Conclusion: In postmenopausal women with long-standing type 2 diabetes, vitamin D3 supplementation at levels similar to 942 IU/day increased isometric handgrip strength but had no effect on glycaemic management.