Aim: Evaluation of knowledge and practice of disposal of leftover and expired medicine among MBBS students. Methods: One hundred male and female medical undergraduates participated in the study. Participants were informed and gave their consent by signing a consent form. Personal information was collected, including names, ages, genders, and more. The number of unused medications, their origins, the most common drug class, and the dosage form were all recorded. Statistical tests were performed on the data gathered. Results: We can see that 54 percent of consumers verify the medication's expiry date before making a purchase, whereas 21 percent do not and 25 percent are unclear. 42% throw away, 13% give to a hospital, 18% hand out to loved ones, and 27% go back to the pharmacy. When asked what they do with stale medicine, the majority (57%) say they dump it down the drain, while 15% say they donate it to loved ones and just 11% say they throw it away. An overwhelming majority (84%) believed that there was a potential for damage to the environment and human health from the incorrect disposal of unused and expired pharmaceuticals. Conclusion: This study demonstrated that the awareness of proper and safe drug disposal of left over or expired medicine among the medical students is quite fair. To make it moreeffective, the concerned authorities need to implement educational programs regularly for general public and medical students.