Background: To compare low doses of intravenous esmolol, labetalol and lignocaine for attenuation of haemodynamic response to laryngoscopy and endotracheal intubation. Materials & Methods: Seventy patients of ASA physical status I or II were enrolled. Complete demographic and clinical details of all the patients was obtained. Patients were be randomly allocated into the following groups containing twenty-five patients each:Group receiving esmolol (Group A), Group receiving labetalol (Group B) and Group receiving lignocaine (Group C). Laryngoscopy and endotracheal intubation with appropriately sized tube was done. Readings of hemodynamic parameters were taken at different time intervals. All the results were recorded in Microsoft excel sheet and were subjected to statistical analysis using SPSS software. Results: While comparing the hemodynamic response at different time intervals, significant results were obtained. Hence; Labetalol was accompanied by minimal attenuation of haemodynamic response in comparison to esmolol and Lignocaine. Conclusion: Haemodynamic alterations are usually observed during laryngoscopy and endotracheal intubation. Labetalol is an effective and safe drug to be used for attenuation of sympathomimetic responses to endotracheal intubation.