Objective: The objective of this study was to assess the knowledge, attitude, and practice of health-care providers regarding the utilization of out-of-date medications and the appropriate disposal of left-over medications at a tertiary care hospital. Methods: A cross-sectional study design was employed, and a questionnaire was developed to collect data from health-care providers at the tertiary care hospital. The questionnaire included sections to assess the participants' knowledge regarding the utilization of out-of-date medications and the proper disposal of left-over medications. Additionally, questions were included to evaluate the attitude of health-care providers towards these practices and to gather information about their current practices in this regard. Data analysis was performed using descriptive statistics. Results: A total of 200 health-care providers participated in the study. The results indicated suboptimal knowledge levels among them regarding the utilization of out-of-date medications and the proper disposal of left-over medications. The attitude of health-care providers varied, with some displaying a lack of concern or awareness towards these practices. In addition, a significant proportion of health-care providers reported inappropriate utilization or disposal of out-of-date and left-over medications in their current practices. These findings highlight the importance of implementing targeted interventions and educational programs to improve knowledge, attitudes, and practices among health-care providers in relation to the utilization and disposal of medications. Conclusion: The study revealed a need for interventions to improve the knowledge, attitude, and practice of health-care providers regarding the utilization of out-of-date medications and the appropriate disposal of left-over medications. Targeted educational programs and regular updates on guidelines and best practices should be implemented to address these gaps. Ensuring proper utilization and disposal of medications can contribute to patient safety, reduce medication waste, and minimize environmental hazards.