Background: Vitamin D is now recognized for more than just its importance in regulating calcium and phosphorus in the human body. In the last decade, great interest has been shown of its actions in other systems. Hence, the present study was conducted to assess the status of vitamin D among patients admitted with Acute exacerbation of COPD. Materials & Methods: 120 subjects who were diagnosed as having COPD were included as controls. Serum vitamin D(25-OH-Vitamin D)of these subjects were carried out. Results: In the present study maximum COPD subjects with acute exacerbation were of age group ≥60years i.e. 39.16% followed by <55 years (32.5%). Maximum COPD subjects with acute exacerbation were males (79.16%). 72.5% COPD subjects with acute exacerbation had Vitamin D levels <=20(deficiency). 27.5% subjects had normal Vitamin D levels. Conclusion: The present study showed that in maximum COPD subjects with acute exacerbation had Vitamin D levels <=20 and therefore it can be concluded that low Vitamin D levels were associated with COPD with acute exacerbations.