Background: Diabetic foot ulcers affect approximately 15% of diabetic people worldwide. The present study was conducted to compare the efficacy of silver stream vs povidine iodine in patients with diabetic ulcers. Materials & Methods: 60 diabetic patients with chronic ulcers of both genders were divided into 2 groups. Group I patient received dressing of silver stream. In group II,patients’ received povidine-iodine. Decrease in ulcersize at end of 2 weeks, 4 weeks, 6 weeks, 8 weeks of treatment or till complete healing, number of ulcers showing complete or partial responsiveness, numberofpatients in both groupin whichulcer persisted till 8 weeks. Results: Group I had 17 males and 13 females and group II had 18 males and 12 females. The difference was non- significant (P> 0.05).% reduction of size of diabetic ulcer was 87% in group I and 35% in group II. The difference was significant (P< 0.05). Complete response was seen in 24 in group I and 15 in group II, partial in 6 in group I and 10 in group II and no response in 5 in group II. The difference was significant (P< 0.05). Conclusion: Silver-based dressing had better results in comparison to povidine- iodine dressing in the management of diabetic foot ulcer.