Aim: Our aim was to compare the effectiveness of ketamine –dexmedetomidine combination and ketamine-midazolam combine on analgesia and sedation for patient undergoing minor procedure under TIVA. Methods: All the patients selected for the study were divided into two groups of 40 in each group. Group KD- ketamine and dexmedetomidine .Group KM- ketamine and midazolam. Patients in group ketamine-dexmedetomidine (KD) received intravenous (IV) dexmedetomidine (1 µg kg-1) diluted in 10 ml (1ml =10mcg) syringe over 10 minutes, before intervention, followed by 1 mg kg-1 of IV ketamine. Patients in group ketamine-midazolam (KM) received IV midazolam (0.05 mg kg- 1) in 10 ml syringe (1ml =0.25 mg) over 10 minutes, before intervention, followed by 1 mg kg-1 of IV ketamine. The hemodynamics, pain and sedation scores, and recovery time for all patients was recorded. Results: Intra operative evaluation showed a significant reduction in the mean HR in the KD group from 15 min onwards.SBP was evaluated in the study and there was a significant reduction the KD group as compared to the KM group. Postoperatively VAS scores were compared and there were significantly lower VAS scores in the KD group as compared to the KM group. Sedation scores were compared as well but there was no significant difference seen between the two groups. The time to first analgesic requirements were higher in the KD group as compared to the KM group. Conclusion: Dexmedetomidine and ketamine is a better alternative to midazolam and ketamine combine in total intravenous anaesthesia in short surgical processes