INTRODUCTION: Poisoning by organophos phosphorous Pesticides (OP) has reached epidemic proportions in most parts of the world, particularly in developing agrarian countries, where the toxicity of available poisons and paucity of appropriate medical facilities ensure a high fatality rate. AIM OF THE STUDY: To estimate serum Amylase levels in acute organophos phorus compound poisoning. To find out its relationship with clinical severity and outcome MATERIALS AND METHODS: Patients presenting with Organophos phorous poisoning were the study subjects. Patients with organophos phorus compound poisoning admitted to the hospital during the study period,100 were included in the study. mahatma gandhi memorial hospital, warangal telangana (MGMH) March 2018 To October 2019 For A Period Of 20 Months. OBSERVATION AND RESULTS: In my study The incidence was higher (40%) in the age group of 21-30 followed by (36%)in the age group of 31-40.In DR,M.G.R university study ,the incidence was similarly higher 40% in %) in the age group of 21-30 followed by 36% in the age group of 31 to 40. CONCLUSION: Of the 100 patients in our study 33 patients (33%) had normal serum amylase level ; 67patients (67%) had elevated serum amylase level which is very significant.