Background: Over the last ten years, there has been a notable narrative of achievement and advancement in the field of endoscopic imaging applied to the small intestine. The small intestine comprises the duodenum, jejunum, and ileum, spanning from the pylorus to the ileocecal valve. To study the clinical profile and endoscopic analysis in small bowel diarrhea in tertiary care centre. Materials & Methods: The present study was conducted over a time period of 2020-2021 at IPGMER Kolkata.A total of 100 subjects were enrolled. Colonoscopy and small bowel endoscopy due to small bowel diarrhea were examined. The factors that showed significance in the initial univariate analysis were subsequently incorporated into the multivariate analysis. The data was analysed using SPSS software. A p value < 0.05 was considered statistically significant. Results: A total of 100 consecutive patients who underwent gastrointestinal endoscopy to investigate chronic diarrhea were identified. Baseline characteristics are examined as the mean age was 56.42 years, and 44% patients were male. Conclusion: Small bowel endoscopy was recommended in cases where colonoscopy yielded negative results, especially for patients presenting with notable weight loss.