Keloids and hypertrophic scars are common dermal conditions characterized by excessive scar tissue formation, causing functional and aesthetic impairments. Traditional treatment modalities often yield suboptimal results and limited success. This paper presents a case series analysis of five patients, including three keloids and two hypertrophic scars, who underwent treatment with dermal matrix substitutes and skin grafting at the Department of Plastic Surgery, MGM Superspeciality Hospital. The outcome analysis, conducted after six months, revealed promising results for hypertrophic scars while highlighting the need for further treatment in keloids due to the development of peripheral hypertrophic scar rims. Triamcinolone injections were administered to address this issue effectively. This paper aims to evaluate the efficacy of dermal matrix substitutes in the management of keloids and hypertrophic scars, emphasizing their potential benefits and areas for improvement.