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Volume 12 Issue 3 ( July-September ) 2023

Original Articles

Study of liver diseases in pregnancy & the maternal outcomes
Dr. Ankit Mahajan, Dr. Akshita Gupta

Background: The liver is one of the many organs affected by the physiological & hormonal changes that occur during pregnancy. Many hepatic disorders diagnosed before or during antenatal period can stay unaffected, go into remission or get exacerbated during pregnancy. Materials and methods: This prospective study was conducted in the department of obstetrics and gynaecology and department of gastroenterology in IPGMER Hospital over a period of one year ( July 2020 to June 2021). Pregnant womenwere examined clinically after taking detailed history. History of close contact with cases of viral hepatitis, parentral drug use, multiple drug transfusions, exposure to blood and blood products, history of hemodialysis was specifically asked. Patients underwent routine lab investigations and special investigations like CT & Peripheral blood films. Results: We screened a total of 22654 pregnant females & about 940 of them had liver disorders with total overall prevalence of about 4.1%. The prevalence of ICP was most common with 588 cases (2.59%), Hyperemesis gravidarum 120 cases (0.52%), chronic carriers of HBV 104(0.45%), Acute hepatitis A 86 (0.37%), acute hepatitis B 12 (0.052%), hepatitis C 6 cases (0.02%), hepatitis E, 2 cases ( 0.008%) & HELLP syndrome with 22 cases (0.09%) & no case of AFLP was observed. Conclusion: Liver disease can complicate the pregnancy in a dramatic and tragic fashion. Awareness, improved recognition and understanding of liver diseases and multidisciplinary approach can diminish maternal and fetal morbidity and mortality.

 
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