Aim: To compare the outcomes of perianal surgery wound healing when utilizing a silver colloidal solution spray versus a povidone iodine sitz-bath. Materials and Methods: A prospective study was conducted in the department of surgery, involving 100 patients who underwent perianal surgery and had an ASA classification of I or II. A total of 100 participants were subjected to random assignment, with half of them being allocated to Group A, where they received a silver colloidal solution spray, and the other half being assigned to Group B, where they underwent a sitz bath twice daily in conjunction with povidone iodine. The assessment of weekly pain score and patient satisfaction score was conducted using visual analogue scales. Results: The overall outcome of the patients in group A and group B was categorized as "excellent" or "good" in 70% and 80% of cases, "adequate" in 24% and 16% of cases, and "poor" in 6% and 4% of cases, respectively. Conclusion: Based on our findings, it can be inferred that the utilization of povidone-iodine in conjunction with sitz bath exhibits potential efficacy in the prevention of surgical site infection, when compared to the application of silver colloidal solution spray.