Background: Pain is one of the most common reasons for patients to visit the emergency department.The present study was conducted to compare IV acetaminophen and IV opioid for patients presenting to emergency department with acute pain condition. Materials & Methods: 60 patients admitted in emergency department for pain of both genders were divided into 2 groups of 30 each. Group I received 1 g IV intravenous acetaminophen over 5–10 minutes and group II received Morphine 0.1 mg/kg IV over 5–10 minutes. Pain score was recorded at 30 minutes and 60 minutes. Patient satisfaction was measured using a 5-point Likert scale. Results: Group I had 32 males and 28 females and group II had 35 males and 25 females. The mean VAS at 30 minutes in group I was 6.5 and in group II was 6.7 and at 60 minutes was 2.1 in group I and 2.0 in group II. The difference was non- significant (P> 0.05). There was 1 dissatisfied patient in group I, 4 neutral in group I and 2 in group II. 20 satisfied in both group I and II and very satisfied in 5 in group I and 8 in group II respectively. The difference was non- significant (P> 0.05). Conclusion: IVacetaminophen provided comparable degrees of pain alleviation to opiates/opioids post treatment in individuals coming to the ED with a variety of pain disorders.