Background: Orthopedic injuries can significantly impact an individual's quality of life. However, limited studies have investigated the impact of orthopedic injuries on quality of life in public health settings. This study aimed to investigate the impact of orthopedic injuries on quality of life in a public health setting Material and Methodology: A cross-sectional study was conducted among 500 participants aged 18-65 years, recruited from a public health setting. Data was collected using a self-administered questionnaire, and the impact of orthopedic injuries on quality of life was assessed using the Short Form-36 (SF-36) questionnaire. Descriptive statistics and regression analyses were used to analyze the data. Results: A total of 35% of participants reported having experienced orthopedic injuries, with fractures being the most common. Orthopedic injuries were found to have a significant negative impact on quality of life, with participants reporting limitations in physical activity, emotional well-being, and social functioning. Factors such as age, gender, and type of injury were found to be associated with the impact of orthopedic injuries on quality of life. Conclusion: The study highlights the significant negative impact of orthopedic injuries on quality of life in public health settings. The findings suggest the need for improved management of orthopedic injuries in public health settings to enhance the quality of life of affected individuals. Keywords: Orthopedic injuries, Quality of life, Public health.