Background: Cancer is emerging as an important global disease burden among various other non-communicable diseases. It is of prime importance to study the pattern of occurrence of these cancers so that adequate steps could be taken to manage and prevent these malignancies Aim: relative proportion of various cancers among patients attending a tertiary care cancer hospital in Madhya pradesh, India. Materials and Methods: this retrospective study was done in a tertiary care hospital in Bhopal, Madhya pradesh, India. A total of 3631 cancer patients with pathologically confirmed malignancy were included in this study. All such patients with proven malignancy registered from January 2020 till December 2022 were included. Results: The sex distribution male to female was 0.98:1. Among men the commonest malignancy was head and neck cancers, followed by lung and gastrointestinal malignancies. Among females cancer cervix was found to be the commonest malignancy followed by carcinoma breast. Conclusion: our study data coincided with the national data which also shows that head and neck cancer is the commonest cancer among males and cervix cancer is the commonest cancer among females. Overall, head and neck cancers were the commonest malignancy among both males and females combined. Appropriate strategies thus have to be formulated for management and prevention of these cancers accordingly. Keywords: Cancer, breast cancer, lung cancer, hospital based cancer study.