Objectives: Congenital heart diseases (CHDs) are the most common birth defects, responsible for nearly one third of all congenital birth defects. CHD is often associated with malnutrition and failure to thrive, the prevalence being as high as 64% in developed countries of the world. We conducted this study to find out the clinico-epidemiological profile of patients with CHD admitted for percutaneous transcatheter intervention (PTI), to evaluate anthropometric profile of children with CHD who underwent PTI and to study immediate and 6 months post procedural clinical outcome. Methods: This is a prospective observational cohort study which is being conducted among patients with CHD underwent PTI. Results: 85 cases were managed successfully with PTI with favorable immediate and 6 moths’ outcome. The commonest CHD treated with PTI was PDA. CHD were found to be more common in females. Commonest symptom was dyspnea. No major complication (except for one event of ASD device embolization) observed with reduced hospital stay. Pediatric age group patients required general anesthesia but the remaining patient were treated with local puncture site anesthesia only. Pediatric age group patients especially < 5 years of age get benefit in terms of physical growth parameters too. This single study encompassing all CHD which are amenable for percutaneous transcatheter intervention. Conclusion: PTI in CHD with suitable anatomy are very safe procedures with excellent immediate and 6 months follow up outcomes irrespective of age. Malnourished children of less than 5 years of age showed significant catchup growth in follow up.