Background: Dyslipidemia is inseparably associated with atherosclerosis - the widely prevalent pathological process, which is undoubtedly the cause of the most fatal and disabling disorders in man in current times. The present study was conducted to compare the efficacy of atorvastatin and rosuvastatin on various aspects of lipid profile. Materials & Methods:100 patients with abnormal lipid profile attending the OPD/Wards of Department of Medicine, Guru Nanak Dev Hospital, attached to Government Medical College, Amritsar (Pb)were randomly divided into 2 groups of 50 each, Group A and Group B. Group A was put on Atorvastatin 20mg daily and Group B was put on Rosuvastatin 20mg daily. Results: Out of 50 patients, males were 26 and females were 24. The mean ±S.D. values of various parameters of 100 patients in Group A and Group B. In group A serum total cholesterol, Serum Triglycerides, VLDL-C, LDL-C and HDL-C were 256.54±33.79 mg%, 284.52±72.26 mg%, 56.90±14.45 mg%, 160.25±31.09 mg% and 39.38±5.17 mg% respectively whereas in group B these values were 244.82±32.52 mg%, 250.18±38.20 mg%, 50.03±7.65 mg%, 158.08+31.63 mg% and 36.71 ±2.75 mg% respectively. The difference was significant (P< 0.05). There were 5 cases in group A and 4 in group B having dyspepsia, 1 case in group A and 2 cases in group B of myalgia. Conclusion: Both Atorvastatin and Rosuvastatin were comparable in dyslipidemic groups. Key words: Atorvastatin, Dyslipidemia, Rosuvastatin