Original Articles
ANALGESIC ACTIVITY OF THE FRUIT EXTRACT OF AVERRHOA CARAMBOLA | |
Biswa Nath Das and Muniruddin Ahmed | |
This experimental study was done to investigate analgesic activity of fruit extract of Averrhoa carambola in Swiss-Albino mice. Analgesic activity was assessed by acetic acid-induced writhing method (for peripheral action) and radiant heat tail-flick test (for central action). For both tests, healthy Swiss-Albino mice of either sex weighing 20-25 g were used for the test; twenty-four mice, aged 4-5 weeks, were randomly selected and divided into four groups with six animals in each group. Each group was given a particular treatment i.e. control, positive control and the two different doses of the extract. In the acetic acid-induced writhing test, the extract in doses of 200 and 400 mg/kg showed 37.13% (p < 0.001) and 42.76% (p < 0.001) inhibition of writhing respectively. In radiant heat tail-flick method the crude extract produced 33.65% and 40.88% elongation of tail flicking time 60 minutes after oral doses of 200 and 400 mg/kg body weight respectively. |
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