Surgery is a medical procedure involving physical as well as mental stress of an individual. It results in various inflammatory and catabolic pathways in the humans. Proper nutritional status of the individual will be helpful in early recovery of the patient from the stress of surgery and also results in good prognosis of the procedures. Though malnutrition and orthopedic surgery complications are known to be significantly related in about 50% of hospitalized patients, proper knowledge is not available. Previous nutritional assessment studies could not be validated as these studies included few screening study parameters. So, the present study is aimed to determine the impact of nutritional status on major orthopedic surgery of the patients as an attempt to obtain more valid related information. The patients attending the Orthopedics department, Maheshwara Medical College, Chitkul between March 2022 and February 2023 were included in study. The study is done in 200 patients after obtaining ethical committee clearance as per the inclusion and exclusion criteria.The 200 patients were categorized into two groups, one group with good nutritional status and another group with under nutritional status. The outcome of the patient, post-operative complications, duration of the discharge were compared and analyzed between the two groups.Malnourished patients were confirmed by CONUT score. Out of 100 patients in group with good nutritional status 20 patients and 63 patients in malnutritional group experienced at least one postoperative complication. The average duration from admission for surgery till discharge was more i.e., 42 days in the malnourished group while it was about 23 days in the nourished group. Similarly, the values of serum albumin, total lymphocyte and total cholesterol levels were found to be lowered in the malnourished group as shown in table. Upon analysis, it was found that the albumin score, lymphocyte score, cholesterol score and CONUT score were significantly lowered in the malnourished group when compared to the control well-nourished group as in table. In our study, albumin lymphocyte and cholesterol levels were found to be lowered significantly in the malnourished group and it resulted in delayed recovery of the patients with increased risk of post-operative complications in the patients who have undergone major orthopedic surgery. The present prospective research confirms the association of major orthopedic surgery with outcome and the nutritional status of the patients. It can be concluded from our study that when compared to well-nourished patients, the malnourished patients are having higher risk of post-operative recovery, mortality and hospitalization stay.