Background: The Electrocardiogram (ECG) records the electrical activity of the heart at the skin surface, A good quality 12 lead ECG is essential for the evaluation of almost all cardiac patients. Stimulus for every normal ventricular contraction (sinus beat) begins in the right atrium (RA) called the sinus node (SA). The normal ECG consists of P, QRS, T wave pattern and sometimes U wave also. In normal sinus rhythm P wave precedes each QRS complex and the rhythm is regular.Aim of the Study: To know the normal variations of Electrocardiogram is healthy adults.Materials and Methods: This study has been conducted in the department of General Medicine, Apollo Medical College, Chittoor, for the period of 6 months. Results: We have included 460 number of participants in this study. Out of these 460, Male participants were 255 and Female participants were 205. The age group is involved is between 20 and 70 years. The most common changes observed were T wave inversion.Conclusion: Although most ECG changes found at baseline could be considered as a normal variation, they may progress to more severe heart complications as the subject ages. The results of this study also validate ECG findings of previous studies and underline that diagnostic criteria should be based on gender and age.