The COVID-19 spread and outburst since December, 2019 lead to many serious complications. Old age people and the patients with co-morbid conditions like hypertension, Diabetes and COPD, are more susceptible to severe Covid-19 disease. We searched the related articles via Medline/PubMed, Scopus, PMC, google scholar and Web of Sciences. In this review we included, original research articles, Case reports and Meta-Analysis. We observed that the biochemical biomarkers like interleukin-6, Ferritin, C-reactive protein, lactate dehydrogenase were elevated in COVID -19 patients. Many studies showed the association of inflammatory biomarkers and severity of COVID -19 Disease. The levels of these biomarkers are highly elevated in critically ill or non-survivor COVID -19 patients. Hence these inflammatory parameters can be useful as laboratory biomarkers and could help to the clinician/physician to rapidly identify the severity of COVID -19 disease.