Aim: The aim of this study is to correlate USG-guided fnac of the liver with cytopathological diagnosis. Material and Methods: This is a prospective research that includes a total of one hundred different instances of liver lesions that were identified either clinically or radiologically. In each and every one of the instances, an abdominal ultrasound was performed. The echogenicity of the liver lesions was analyzed, and they were classified as either solitary, numerous, or diffuse. Results: There were a total of one hundred cases. Diagnosis was attainable in 92 out of 100 instances, resulting in a diagnostic yield of 92%. The great majority of 80 patients (80%) were diagnosed with malignant liver aspirates. The main malignant liver lesions accounted for 42 of these 80 instances, which is 52.5% of the total. 39 of these instances were hepatocellular carcinoma, while the other two cases were primary NHL. There were a total of 40 cases. 31 of the 39 cases of HCC had a single site of origin (SOL), whereas 8 of the cases had multiple sites of origin (SOL). Nine of the patients in the metastatic carcinoma group had a single lesion, whereas the other thirty patients had numerous lesions. Both instances of NHL manifested themselves as having many foci of disease. A good correlation was found between the ultrasound diagnostic and 74 out of 92 instances. Conclusion: Cancerous tumors were the most prevalent kind of liver lesion, and the prevalence of primary and metastatic liver tumor deposits was comparable. In the majority of the instances, HCC was found to be a single lesion, and deposits were shown to be associated with several SOLs.