Introduction- Hypoxic ischemic encephalopathy is a significant cause of morbidity and mortality and a common indications for admission of sicknew-born care unit (SNCU). Perinatal asphyxia leads to multiorgan involvement among that cardiac involvement is quite common. Further cardiac investigation on follow-uparerequired for better understanding and early diagnosis of associated heart disease. Objectives- 1. To compare the cardiac changes before 7 days of postnatal life in term neonates of hypoxic ischemic encephalopathy with healthy terms neonates. 2 To compare the cardiac changes at 3 months of follow-up in term neonates with hypoxic ischemic encephalopathy and healthy term neonates. Methods- This was a hospital based prospective study . Data regarding socio-demographic details, details of clinical presentation of asphyxiated newborn, antenatal, natal and post natal history was collected. Two dimensional echo cardiography , Chest X-ray findings were also recorded. Results:-Among 80 neonates, 3 certified ,6 not given consent and 7 were loss of follow up seen. Hence 64 neonates assessed in which 34 were case and 30 were control. Among 34 cases with in 7 postnatal day having 17(50%) atrial septal defect, 3(8.8%) ventricular septal defect, 5 (14.7%) atrial septal defect and ventricular septal defect and 9(26.5%) were having no cardiac abnormality. In 30 controls 8(26.7%) atrial septal defect and 22(73.3%) having no cardiac abnormality. Conclusion:- Majority of cardiac morbidity among hypoxic ischemic encephalopathy and cases resolves by 3 months of age. Two dimension echocardiography and follow up helps in early detection and intervention may reduce infant mortality and morbidity.