Background:Low back pain (LBP) remains a musculoskeletal condition with an adverse societal impact. Globally, LBP is highly prevalent and a leading cause of disability. The estimated rate of incidence of low back pain ranges from 60%–80% of adults at some point in their lifetime and estimated the annual worldwide low back pain incidence in adults is 15% and the point prevalence to 30%, with recurrence of low back pain being common. Physiotherapy plays a key role in management and treatment of lower back pain. Objective:The objective of this study is to find out the effectiveness of thoracolumbar fascia activation with McKenzie exercises vs only McKenzie exercises for the patients who suffer from lower back pain. Materials and Methods:A total of 30 individuals between the age of 18-50 were taken in this study having symptoms with chronic low back pain. with Inclusion Criteria 1) Back pain (more than 2 weeks). 2) Positive special test Postural low back pain. 3)Degenerative origin with or without radiation. 4) Age – 18- 50 years. Participants taken in study and were randomised into two different groups, Group A treated with thoraco-lumbar fascia activation and McKenzie exercises and Group B treated with only McKenzie exercises. Results and Conclusions:The results of this study indicate that both thoracolumbar fascia activation with McKenzie exercises is effective in patients with low back pain. The differential effectiveness between thoracolumbar fascia activation with McKenzie exercises and only McKenzie exercises may be attributed to the active involvement of patients in the thoracolumbar fascia activation with McKenzie exercises treatment process. This active engagement may explain the superior pain relief and functional improvement associated with low back pain.