Background: systemic fungal infections are superficial, cutaneous, and subcutaneous infections. These infections gravely threaten the healthcare system. The present study was conducted to assess prescription patterns of systemic antifungal medications in critically ill patients. Materials & Methods: This study was conducted on 145 patients in the Department of Pharmacology in collaboration with the Department of Critical care Medicine and the Department of Medicine of King George’s Medical University (KGMU). Clinical symptoms and investigations were recorded. Prescription patterns of systemic antifungal medications was recorded. Results: The majority of the patients were 12-31 years old [63(43.45%)], followed by 52-71 years old [34(23.45%)], where the mean age was recorded [43.11±20.09] years. Statistically, a significant difference was observed. Most of the patients were males [74(51.03%)], followed by females [71(48.97%)]. Out of 160 comorbidities diagnosed, the majority of the patients had no comorbidities [96(60.00%)], followed by patients who had diabetes [22(13.75%)], peptic ulcer disease [11(6.88%)] and so on. The Charlson Comorbidity Index showed that the majority of the patients had mild comorbidities [42(65.63%)], followed by moderate comorbidities [16(25.00%)], and this difference was statistically significant. The majority of the patients were referred from trauma [118(83.10%)], followed by referred from department of medicine [8(5.63%)], QMH [7(4.93%)] and so on. The majority of the patients were prescribed Inj Caspofungin [82(56.55%)], followed by Inj. Fluconazole [44(30.34%)], Inj Anidulafungin [12(8.28%)]. Statistically, a significant difference was observed in antifungal agent prescription to patients. Charlson comorbidity index, Apache score, Sofa score and duration of antifungal prescription shows a significant positive correlation with each other. Conclusion: Caspofungin was the most often used antifungal medication. The usage of more modern antifungal drugs is also growing. It was observed that most patients in were age group 12-31 years; have systemic antifungal medications, especially in males.