Background and Objectives: COVID-19 refers to the infectious disease induced by the novel coronavirus. At present, no definitive treatment for COVID-19 has been established. Consequently, it becomes crucial to ascertain the severity of the illness in patients upon initial admission. In light of this, the investigation of biomarkers assumes significance. The objective of this study was to evaluate the diagnostic and early prognostic significance of C-reactive protein (CRP) and lactate dehydrogenase (LDH) levels in individuals having COVID-19. Methods: In our study, we conducted an assessment of the associations between pertinent routine laboratory test outcomes and the severity of disease in patients diagnosed with COVID-19 who were admitted to a tertiary level hospital and medical college in Central India. The patients were categorized into two groups based on the severity of their condition. Our analysis aimed to identify potential biomarkers by examining the disparities in these findings between the two groups categorized by disease severity. Results: The median age of patients in the severe disease group was found to be significantly higher compared to the non-severe group. Furthermore, the levels of CRP and LDH in the severe disease group also exhibited a statistically significant increase when compared to the non-severe group. Conclusion: In the early stages of COVID-19, there exists a positive correlation between the levels of CRP and lactate LDH and the presence of lung lesions. This correlation suggests a potential association with disease severity. Given that LDH and CRP levels can potentially serve as indicators of pulmonary function, they hold promise as predictors for COVID-19-related respiratory failure.