Introduction: Metabolic syndrome (MetS) is a cluster of metabolic disorders associated with glucose intolerance, central obesity, hypertension, and dyslipidemia. Postmenopausal women are at an increased risk of developing MetS due to changes in hormone levels, particularly estrogen and androgen. Estrogen deficiency during the menopausal transition affects lipid metabolism, insulin resistance, blood pressure regulation, and fibrinolysis, contributing to the development of cardiovascular disease (CVD) in this population. Additionally, thyroid dysfunction, especially hypothyroidism, can further amplify the risk of CVD and metabolic disturbances. The association between abnormal levels of thyroid-stimulating hormone (TSH) and metabolic disturbances in postmenopausal women with MetS is still debated, necessitating further research. Aims and Objectives: The objective of this study is to investigate the correlation between serum TSH concentrations and components of MetS among postmenopausal women with MetS. The aim is to enhance clinical management strategies for this patient population. Methods: A cross-sectional observational study was conducted on 150 randomly selected postmenopausal women aged 45 to 65 who visited the General Medicine OPD. The diagnosis of MetS was based on the presence of three or more components according to the NCEP ATP III Criteria. Exclusion criteria included smoking, alcoholism, chronic or acute illnesses, inflammatory diseases, and hormone replacement therapy. Various parameters, including age, age at menopause, TSH levels, blood pressure, waist circumference, fasting blood sugar, triglyceride levels, and high-density lipoprotein cholesterol levels, were measured and recorded. Statistical analysis was performed using SPSS 18.0 software, employing analysis of variance (ANOVA) and Pearson correlation coefficient tests. Results: Among the 150 postmenopausal women, 120 were diagnosed with MetS, while 30 did not have MetS. The average age of the participants was 62.11 years. Women with MetS had slightly lower average ages than those without MetS. The average TSH level was 3.35 mIU/L for all women, with higher levels observed in women with MetS. Blood pressure, waist circumference, fasting blood sugar, and triglyceride levels were higher in women with MetS, while high-density lipoprotein cholesterol levels were lower. The study also categorized the participants into euthyroid, hypothyroid, and hyperthyroid groups based on TSH levels, revealing variations in metabolic syndrome components among these groups. Conclusion: This cross-sectional observational study provides initial insights into the correlation between serum TSH concentrations and components of MetS in postmenopausal women. The findings suggest a potential association between thyroid dysfunction and metabolic disturbances in this population. Further research is required to establish a clearer relationship between abnormal TSH levels and metabolic syndrome components and to differentiate the symptoms of thyroid dysfunction from those associated with ovarian dysfunction. The results of this study can contribute to the optimization of clinical management strategies for postmenopausal women with MetS, aiming to reduce the risk of cardiovascular complications.