Aim: The purpose of this prospective randomised study was to assess the maintenance, emergence, recovery parameters and hemodynamic stability with sevoflurane or Desflurane for any surgical procedure under general anaesthesia lasting for >120mins in Indian patients with BMI>27.5. Material and methods: Total of 100 Patients were divided in to 2 groups. Group І (D) – anesthesia was induced using standard induction and maintained O2 and desflurane and Group ІІ (S) – anesthesia was induced using standard induction and maintained with O2 and sevoflurane. Patient demographics(age, sex, height, weight,BMI), medical history(ASA grading), maintenance of anaesthesia (MAC every 15minutes intraoperatively), emergence (time duration forextubation), recovery (durations for ability to follow commands and orientation to time, place and person and time to PACUdischarge) and hemodynamic stability (SBP, DBP,HR measured preoperative,intraoperatively every 15mins and postoperatively)] were recorded. Results: We found that there were no significant differences in MAC requirements during maintenance of anesthesia. The time to extubation, time to follow verbal commands, time to orientation to time place and person and time to PACU discharge were significantly shorter (P<0.001) with desflurane as compared to sevoflurane. Intraoperative BP and HR did differ statistically between the two groups at some time points (P<0.001) but these differences were clinically insignificant and warranted no additional intervention. Conclusion: Both Desflurane and Sevoflurane provide comparable clinical hemodynamic stability and maintenance of anesthesia but the emergence and recovery were significantly faster after Desflurane thus contributing to fast tracking and early discharge of patients from PACU.