Immunocompromised patients, caused by HIV-infected patients, patients of chronic renal failure, patients receiving chemotherapy, have a reduced ability to fight infections making them susceptible to CNS infection, increasing their morbidity and mortality. Radiologic imaging with CT and MRI is often employed to supplement clinical evaluation in cases of suspected CNS lesions in these patients. Therefore the objective of this study is to study the usefulness of CT and MRI in characterization and differentiation of CNS lesions, and estimate the incidence of most common intracranial lesion in immunocompromised adult patients. All immunocompromised patients presenting with neurological symptoms underwent CT and MRI scan of the brain. Imaging findings were analyzed and described along with clinic-pathological data as appropriate. The different intracranial lesions in HIV infected patients were Tuberculosis (54.20%), HIV Vasculitis (14.20%), Toxoplasmosis (11.40%), Neurocysticercosis (8.50%), HIV Encephalitis (5.70%), Cryptococcosis (2.80%) and Progressive Multifocal Leukoencephalopathy (2.80%). Overall CT sensitivity was 28%, Positive predictive value (PPV) 100%, Diagnostic accuracy 28%, and MRI had 100% sensitivity and PPV of 100% for detection of CNS lesions in immunocompromised patients. Overall, the most common intracranial lesion in immunocompromised host in the present study is Tuberculosis constituting to 40% incidence, followed by HIV Vasculitis and PRES with 10% incidence each. MRI is an excellent tool for the imaging of brain in immunocompromised patients with neurologic disease, with CT playing a complimentary role.