Introduction: Treatment of molar furcation defects remains a considerable challenge in clinical practice. Furcation defects treatment can vary according to the type and location of the defects. Regenerative procedures are one of the treatment modalities in furcation involvement. Objectives: The aim of this study designed to comparatively evaluate the efficacy of platelet rich fibrin membrane and chorion membrane with bone graft (Demineralised Freeze Dried Bone Allograft) in the management of grade II furcation defects. Materials and methods: This study was conducted clinically on fortysites with grade II furcation defects. Patients were divided into two groups: Group 1 PRF And DFDBA and Group 2 included Chorion Membrane and DFDBA. Vertical Furcation Depth, Horizontal Fucration depth, relative attachment level, were measured at baseline,3, 6 and 9 months . Radiographic examination was performed at baseline,6, and9months to evaluate bonefill in the furcation defect. Results and Conclusion: There was a significant reduction of clinical parmeters and defect fill with autogenous PRF and Chorion membrane with DFDBA in Grade II furcation defects