Background: In India, on 30th January 2020, the first case of COVID-19 was reported. Several co-morbidities and demographic factors are associated with mortality in COVID-19 patients. The present study was undertaken to evaluate risk factors, comorbidities, and mortality of COVID19 positive patients at tertiary care centre in Indian population.Methods: A total 640 COVID-19 positive patients of age 13 years and above were enrolled in the study and evaluated for risk factors, comorbidities, biochemical markers, and outcomes. These variables were compared among survived and dead of COVID-19 positive patients. Results: Out of 640 participants, 475(74.2%) were alive and 165(25.8%) died. History of contact with COVID-19 positive patients (71.6) was found to be significant risk factor. Cough (69.7%), breathlessness (63.6%), fever (60.6%) were the commonest clinical features. There was significant difference between survived and dead with respect to breathlessness, (p=0.0001). Comorbidities leading to increased risk of mortality were hypertension (26.4%), Diabetes (25.3%) and COPD (20.6%). Inflammatory markers were positively correlated with severity of COVID-19, deranged Neutrophil: Leukocyte ratio and CRP being the most sensitive followed by D-DIMER, serum LDH and IL-6. Higher CT severity scores were related to worse outcomes in COVID-19 patients. COVID-19 positive patients with HIV had 100% mortality due to immune-compromised state. Increased mortality was seen in patients who needed O2 therapy and NIV.Conclusion: CARP protocol and nasogastric feeding was found to be more effective to improve outcome in COVID-19 positive patients on NIV, NRBM and O2 masks. Chest physiotherapy, strict glycemic control, adequate hydration, and positive energy have key role in managing COVID-19 positive patients.