Introduction – The most common malignancy of oral cavity is squamous cell carcinoma. Its epidemiology shows marked variation in different geographical regions. Hence the present study is conducted to assess different histopathological feature, which have prognostic and predictive value, which is routinely used by clinicians for planning of multimodality treatment. Material & methods- The cross-sectional study was carried out on total of 400 patients with OSCC who attended the surgical oncology unit of Kalyan Singh Super speciality Institute, Lucknow. Neck dissection was performed in all patients with clinico-radiologically/ FNAC proved positive nodes as well as in patients with large tumor and clinically negative nodes. Follow up program was done. SPSS 20.0 version have been used for the statistical analysis of the data. Results – A total of 400 cases included in this study, who met the eligibility criteria. Majority of study population (67.16%) were in the age group of less than 50year. The buccal mucosa was the most common site of tumor comprising of 187 cases. Most of the cases exhibited maximum depth of invasion >1cm (199 cases) followed by 0.5-1cm (142 cases). Conclusion – Study concluded that there is increasing incidence of OSCC in younger population and male gender who presented late and came with higher stage of disease in this zone of country. There is need of initiating more aggressive community awareness programs to educate individuals, especially in the younger age group.