Aim: This study focused on the outcome of treatment of liver abscess of >5 cm by means of catheter drainage and the use of antibiotics. Material & methods: In this retrospective study, patients with liver abscesses of size >5 cm who had undergone percutaneous pigtail catheter drainage procedure in the department of radiology of our institution were included. The study period was of 1 year. Small-sized abscesses were excluded from the study. A total of 100 patients were included in this study. Results: In this study, a total of fifty cases of liver abscesses were included. Among these, 80 (80%) were male and 20 (20%) cases were female. The age group affected was 21-66 years, with the mean age being 45 years. Fifty percent of the patients had underlying comorbidity, the most common of which was diabetes in 30% of the cases. The most common symptom was fever which was found in 65% (n = 65) of the cases. Abdominal pain was the next most common, seen in 50% (n = 50) of cases. Right lobe was the most common site of occurrence of abscess (n = 55) in 55% of cases. Among the various laboratory parameters, total leukocyte count (TLC) had increased (>11 × 103/μl) in 37 patients equivalent to 70%, serum bilirubin had raised (>1.2 mg/dL) in 15 patients equivalent to 30%, serum total protein was low (1.5) in 10 patients equivalent to 20%. Conclusion: In contradiction to the earlier belief, percutaneous drainage is a safe and effective means of treatment in liver abscesses of >5 cm with high clinical success rate and reduced duration of intravenous antibiotic requirement as well as hospital stay.