Background and Aim: Segmental fractures of tibia are uncommon and are usually caused by a high-energy trauma. They have a high complication rate. Current treatment options are locked intramedullary nailing, external fixators and plaster of paris cast immobilization. Hence the aim of the study was to evaluate the Functional outcome following interlocking intramedullary nailing for segmental fractures of tibia. Material and Methods: The present study was conducted in the department of the orthopaedics, medical college & hospital. A sum total of 42 cases of segmental tibia cases reported and studied. Patients will be followed up for a minimum period of 1 year. Patients were admitted in our with segmental tibia fractures during the described period prospectively and retrospectively with either open or closed segmental tibia fractures with compromised soft tissue and treated with interlocking nail. Results: Maximum numbers of the patients were of the age group of 25 years to 35 years. The mode of injury was accounted in the history and was found that two wheeler injuries was the most common mode of injury. The accounted for 83% o the patients. In our study 28 patients had associated fibula fracture at single level, 8 patients had segmental fibula fracture, 2 patients had double segmental fibula fracture and 2 patients had isolated tibia fracture. Except two patients all patient had fibula fracture above the level of syndesmosis. According to johner and wruchs criteria we got acceptable functional outcome was found in 78% of patients and unacceptable outcome was seen in 22% of patients. Conclusion: Experience regarding appropriate usage of polar screw and tibial entry point makes the surgical procedure easier with excellent functional outcome. Preservation of vascularity of intermediate segment and nontraumatic reduction of fracture fragments requires expert surgical skill.